CryoXtract Blog

In the News: FFPE or Frozen?

Posted by Marie Gouin on Mar 2, 2016 2:03:05 PM

In bioanalysis of tissue specimens, there are two main options for long-term sample storage: formalin-fixed paraffin-embedded (FFPE) samples and frozen samples. An editorial article by Caitlin Smith, (found herenicely outlines the benefits and detriments of each. Though FFPE samples are preferred for immunostaining and morphology, she concludes that frozen samples are preferable to FFPE samples for molecular analysis and native morphology for several reasons. Foremost among them is the higher potential for quality degradation during preparation and storage. Frozen specimens, which do not suffer the same degradation, are particularly necessary for analyses involving mass spectrometry, quantatative real-time PCR, and Western blotting. 

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Topics: frozen aliquotting, bioanalysis, molecular analysis

CryoXtract is Finalist for the SLAS Innovation Award

Posted by Graham Long on Jan 6, 2016 7:46:06 AM

CryoXtract Instruments, LLC will be offering a podium presentation and exhibiting at the Society for Laboratory Automation and Screening (SLAS) annual conference from January 24th-27th in San Diego. CryoXtract is also pleased to announce that their abstract was one of only 9 finalists selected for the SLAS Innovation Award. The $10,000 award is bestowed upon the podium presentation that is "exceedingly innovative and contributes to the exploration of technologies in the laboratory, exceeds a benchmark or milestone in screening or the lead discovery process, or demonstrates an advanced and integrated use of mature technologies." 

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Topics: frozen aliquotting, bioanalysis, DMPK, LC-MS/MS, slas

CryoXtract to Present Webinar on July 22, 2015

Posted by Joe Fraone on Jul 7, 2015 3:15:35 PM

On Wednesday, July 22 at 11am, CryoXtract will present a webinar entitled "Eliminating Freeze-thaw Cycles: Advances in Frozen Biospecimen Preservation and Utilization." This webinar is intended to provide the scientific community with information on new approaches for quick and effective frozen sample processing for experimental applications. 

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Topics: biospecimens, frozen aliquotting, webinars

In the Media: Alzheimer's Study Utilizes Proteomics Panel Technologies

Posted by Joe Fraone on Jun 30, 2015 9:00:00 AM
As Alzheimer’s Awareness Month comes to an end, we note publication of a study of plasma protein biomarkers for this increasingly common neurological disease. The research, published in Translational Psychiatry and found here, sought to identify plasma proteins associated with potential blood-based biomarkers in asymptomatic older twins. The study utilized SOMAScan technology. Results indicated that the plasma protein level of MAP2K4 and MAPKAPK5 may be possible biomarkers of early AD.
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Topics: Press Summaries, frozen aliquotting, proteomics

New Application Note Debuted at SLAS2015 Highlighting GlaxoSmithKline and CryoXtract Collaboration on ex vivo Stabilization of Small Molecules and Peptides

Posted by Joe Fraone on Feb 10, 2015 5:39:43 PM

At this week’s SLAS conference held in Washington, D.C., CryoXtract offered “Ex vivo Stabilization of Small Molecule Compounds and Peptides in EDTA Plasma for LC-MS/MS Analysis Using Frozen Aliquotting,” an application note on its CXT 750 Frozen Sample Aliquotter and its potential for maintaining small molecule and peptide stability. This research, generated in collaboration with GlaxoSmithKline, demonstrates the benefits of the frozen aliquotting solution for applications in analytical chemistry and drug metabolism pharmacokinetics (DMPK) groups, and is a potentially significant development for improving drug stability in serum and plasma samples.

The research demonstrates the benefits of the frozen aliquotting solution as a valuable tool for compound stabilization and bioanalysis. In addition to improving clarity for bioanalysis by lessening the impact of ex vivo degradation and improving the efficiency of frozen sample utilization, frozen aliquotting could also potentially reduce the time required for assay development and validation and greatly simplify sample collection, processing, and handling protocols for bioanalytical efforts. These measures are required to keep the drug molecules sufficiently stable to permit meaningful analysis by mass spectrometry.

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Topics: Conferences, frozen aliquotting

Frozen Sample Aliquotting Can Preserve Quality of CNS Tissue & Biofluid Samples: CryoXtract Poster, ESBB 2014

Posted by Graham Long on Nov 6, 2014 6:56:20 AM

At last month’s annual conference of the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB) in Leipzig, Germany, CryoXtract presented a poster on using frozen aliquotting for the preservation of analytical profiles in neurodegenerative research. The poster, entitled “Preserving Analytical Profiles of CNS Samples for Neurodegenerative Disease Research using Frozen Aliquotting Sample Handling Technology,” detailed potential improvements in sample processing techniques for central nervous system (CNS) disease tissue and biofluids biospecimens.

Freeze-thaw damage to highly sensitive CNS biospecimens can dramatically hinder the growing amount of research in the fields of neurodegenerative disease. By integrating frozen aliquotting into modern neurobiological research, greater access to high quality annotated CNS samples could yield improved diagnostic and treatment options for the growing populations facing diseases such as Alzheimer's and Parkinson's.  

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Topics: biospecimens, biobanking, Conferences, frozen aliquotting, ESBB 2014, CNS tissue

ESBB 2014: CryoXtract Will Present Two Posters and Showcase the CXT350 Frozen Aliquotter

Posted by Graham Long on Oct 19, 2014 4:18:16 PM

CryoXtract Instruments is excited to be presenting two posters and a display booth at the annual conference of the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB) that starts tomorrow in Leipzig, Germany. 

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Topics: biobanking, Microbiome, Conferences, frozen aliquotting, ESBB 2014

Biobanking Industry’s Growing IT Demands Must Be Addressed as Part of Best Practices for Maintaining the Integrity of Research Samples: Interview with CHTN’s Dee McGarvey

Posted by Larry Chin on May 19, 2014 1:38:32 PM

 

DeeShotsThe biobanking industry needs to address growing information technology demands in order to be able to execute on best practices for research now and in the future, said Dee McGarvey, Director, CHTN Eastern Division, University of Pennsylvania, in an interview.

Biobank databases, for example, need to be comprehensive enough to hold large amounts of information and at the same time provide flexibility so that they can connect with a variety of complementary information systems. As the systems are designed and implemented, of primary concern is ensuring security since Patient Health Information (PHI) is involved.

“That’s probably one of the biggest issues that biobanks are working with right now,” McGarvey said. "How do you manage to keep the databases open so we can use them and access them and they can interact with all the other systems? How can we work within this framework and at the same time, maintain the security?”

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Topics: Sample Integrity, ISBER, biobanking, frozen aliquotting, CHTN

Attend ISBER 2014 Workshop: Managing the Past for the Future

Posted by Larry Chin on May 16, 2014 9:30:00 AM

 

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Topics: ISBER, Conferences, frozen aliquotting