CryoXtract Blog

Significantly Decrease the Bioanalytical Impact of Analyte Degradation in Thawed Biological Samples

Posted by Graham Long on Feb 22, 2016 2:25:24 PM

Degradation of molecules in thawed biological samples is one of the biggest challenges for all bioanalytical laboratories. During the January SLAS conference in San Diego, CA, CryoXtract was nominated for an innovation award based on a study of the use of frozen aliquotting for the bioanalysis of labile compounds (found here). During a podium presentation, authors Glenn Smith and Joe Fraone outlined the results of the collaborative study with GlaxoSmithKline.

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Topics: Sample Integrity, biospecimens

In the Media: Failures in Incurred Sample Reanalysis

Posted by Joe Fraone on Aug 4, 2015 5:22:00 PM

Failures in incurred sample reanalysis (ISR) can be very problematic to life science researchers working in drug discovery and regulated bioanalysis. As a tool for confirming reliability of bioanalytical measurements, concerns with and failures of ISR can significantly delay drug development and can be very costly to remedy. An article in AAPS earlier this year (found here) discusses difficulties with ISR imprecision particularly in small molecule studies. 

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Topics: biospecimens, Press Summaries

CryoXtract to Present Webinar on July 22, 2015

Posted by Joe Fraone on Jul 7, 2015 3:15:35 PM

On Wednesday, July 22 at 11am, CryoXtract will present a webinar entitled "Eliminating Freeze-thaw Cycles: Advances in Frozen Biospecimen Preservation and Utilization." This webinar is intended to provide the scientific community with information on new approaches for quick and effective frozen sample processing for experimental applications. 

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Topics: biospecimens, frozen aliquotting, webinars

In the Media: NCCN Hosted Policy Summit

Posted by Joe Fraone on Jun 23, 2015 9:30:00 AM

The National Comprehensive Cancer Network hosted its policy summit on June 8, 2015 in Washington, D.C. Discussions centering around the theme “Emerging Issues in Tissue Allocation” addressed increasing concern in the oncology research community about the proper acquisition and management of highly valuable, and often especially fragile, biospecimen resources.

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Topics: biospecimens, Press Summaries, Conferences

Frozen Sample Aliquotting Can Preserve Quality of CNS Tissue & Biofluid Samples: CryoXtract Poster, ESBB 2014

Posted by Graham Long on Nov 6, 2014 6:56:20 AM

At last month’s annual conference of the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB) in Leipzig, Germany, CryoXtract presented a poster on using frozen aliquotting for the preservation of analytical profiles in neurodegenerative research. The poster, entitled “Preserving Analytical Profiles of CNS Samples for Neurodegenerative Disease Research using Frozen Aliquotting Sample Handling Technology,” detailed potential improvements in sample processing techniques for central nervous system (CNS) disease tissue and biofluids biospecimens.

Freeze-thaw damage to highly sensitive CNS biospecimens can dramatically hinder the growing amount of research in the fields of neurodegenerative disease. By integrating frozen aliquotting into modern neurobiological research, greater access to high quality annotated CNS samples could yield improved diagnostic and treatment options for the growing populations facing diseases such as Alzheimer's and Parkinson's.  

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Topics: biospecimens, biobanking, Conferences, frozen aliquotting, ESBB 2014, CNS tissue

Listen to the Audio: Interview with Andy Zaayenga, Managing Director of SmarterLab and President-Elect of ISBER, 2014-2015

Posted by Larry Chin on May 2, 2014 8:14:05 AM

The following are audio files of the full interview conducted by Larry Chin, Vice President of Business Development at CryoXtract, with Andy Zaayenga, Managing Director of SmarterLab and President-Elect of ISBER, 2014-2015. You can also read the full transcript below.

Challenges Facing the Biobanking Industry:

In a recent interview with CryoXtract’s Larry Chin, Andy Zaayenga, Managing Director of SmarterLab and incoming President of ISBER, discusses the top three challenges facing the biobanking industry today. He cites problems with sample utilization and acceptance of biobanks by the general population as key concerns. Both of these relate to the third problem of biobanks operating alone in silos. Without solid systems of communication and standardization of infrastructure and procedures, improving sample utilization and the public perception of the industry is difficult. ISBER is one organization working towards addressing these issues through initiatives such as its upcoming biorepository locator.

Needs of the Biobanking Industry:

Andy Zaayenga continues his discussion of the top three gaps and unmet needs of biobanks by arguing for improved quality assurance and control in order to preserve sample suitability for research. He again calls for standardization and harmonization of quality assurance procedures, data structures, and annotation of samples to increase accessibility and cross-utilization of samples.  Finally, he highlights ISBER's published best practices and self-assessment tools as key answers to another major gap in the industry. 

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Topics: ISBER, Andy Zaayenga, biospecimens, legacysamples, biobanks, biorepository, biobanking