Eliminate outliers based on sample quality, audit collection sites, and determine fit-for-purpose for retrospective samples. The MxP® Quality Control Plasma assay utilizes proprietary software algorithms to screen metabolomic profiles generated via GC-MS and detect deviations in sample handling.
Topics: Sample QC
The Japanese Society of Pathology Annual meeting is one of the longest-standing and most preeminent pathology meetings in Asia. Over 2,500 researchers and physicians attend the meeting and presentations by a multinational list of experts in the field of pathology. The CXT 353 Frozen Sample Aliquotter, a novel work flow solution for the processing of frozen tissue specimens, is being presented by Asahi Life Science, CryoXtract's exclusive distribution partner in Japan.
With over 700 bioanalytical researchers from major pharmaceutical companies and CROs, this year's Workshop on Recent Issues in Bioanalysis held in Orlando, FL through Thursday of this week is an exciting place for CryoXtract to be exhibiting! Stop by Booth #47 to learn how CryoXtract’s frozen sample aliquotters help preserve the integrity and accuracy of data from bioanalysis in drug discovery and development.
In bioanalysis of tissue specimens, there are two main options for long-term sample storage: formalin-fixed paraffin-embedded (FFPE) samples and frozen samples. An editorial article by Caitlin Smith, (found here) nicely outlines the benefits and detriments of each. Though FFPE samples are preferred for immunostaining and morphology, she concludes that frozen samples are preferable to FFPE samples for molecular analysis and native morphology for several reasons. Foremost among them is the higher potential for quality degradation during preparation and storage. Frozen specimens, which do not suffer the same degradation, are particularly necessary for analyses involving mass spectrometry, quantatative real-time PCR, and Western blotting.
Degradation of molecules in thawed biological samples is one of the biggest challenges for all bioanalytical laboratories. During the January SLAS conference in San Diego, CA, CryoXtract was nominated for an innovation award based on a study of the use of frozen aliquotting for the bioanalysis of labile compounds (found here). During a podium presentation, authors Glenn Smith and Joe Fraone outlined the results of the collaborative study with GlaxoSmithKline.
In a research article published in the January issue of BioPreservation and Biobanking, researchers investigated the ability of CryoXtract’s CXT 350 Frozen Sample Aliquotter to take multiple targeted cores from a single tissue or fecal biospecimen without thawing. Frozen aliquotting preserved both the highly valuable parent sample and the frozen aliquots. Once integrated into a laboratory workflow, the authors state that the CXT 350 can positively impact and maintain biospecimen quality for research.
As the Northeast Regional Sales Manager, Marie Gouin has been supporting sales at CryoXtract since February of 2015. She has a broad range of experience specializing in and encompassing the fields of cardiology, cardiac electrophysiology, clinical imaging, digital pathology and image analysis. Her track record of supporting market acceptance of new and cutting-edge medical, clinical and research technologies has been the center point of her professional career.
Topics: Executive Spotlight
CryoXtract Instruments, LLC will be offering a podium presentation and exhibiting at the Society for Laboratory Automation and Screening (SLAS) annual conference from January 24th-27th in San Diego. CryoXtract is also pleased to announce that their abstract was one of only 9 finalists selected for the SLAS Innovation Award. The $10,000 award is bestowed upon the podium presentation that is "exceedingly innovative and contributes to the exploration of technologies in the laboratory, exceeds a benchmark or milestone in screening or the lead discovery process, or demonstrates an advanced and integrated use of mature technologies."
A recent article in Analytical Chemistry, found here, describes the use of liquid extraction surface analysis mass spectrometry (LESA-MS), to study drug distribution in tissue. While this method is effective at exploring surface distribution, frozen aliquotting enables the precise capture of larger-depth frozen tissue aliquots from specific tissue sections, enabling detailed drug distribution and excretion studies. To learn more about frozen aliquotting, visit http://www.cryoxtract.com/applications/bioanalysis
Topics: Press Summaries